Resveratrol from mulberry extract has the potential to prevent and delay macular degeneration...

Resveratrol from mulberry extract has the potential to prevent and delay age-related macular degeneration (AMD) through several biological mechanisms as follows:

1. Antioxidant activity

Resveratrol can eliminate or inhibit the production of free radicals (ROS), which are important factors that damage retinal cells. (especially RPE cells - Retinal Pigment Epithelium)

Reduce lipid oxidation and prevents the destruction of proteins and DNA in the retina

2. Reduce inflammation (Anti-inflammatory effect)

Inhibits the activity of NF-κB, a protein that controls inflammatory processes.

Reduce the secretion of Inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are involved in AMD pathology.

3. Prevent cell death (Anti-apoptotic effect)

Resveratrol stimulates the expression of proteins that protect against apoptosis, such as Bcl-2.

Inhibiting apoptosis-inducing proteins such as Bax and caspase-3, causing RPE cells to survive longer.

4. Strengthens the function of mitochondria.

Stimulates the expression of SIRT1, an enzyme that helps balance energy in cells.

As a result, the mitochondria work better. Reduce oxidative stress and increases retinal cell repair

5. Inhibit the creation of abnormal blood vessels. (Anti-angiogenic effect)

Reduces the expression of VEGF (Vascular Endothelial Growth Factor), which is the main factor that stimulates abnormal blood vessel formation in wet AMD.

Resulting in reducing blood vessel leakage and retinal swelling.

Summary:

Resveratrol extracted from mulberry works through several mechanisms, including antioxidant protection, reducing inflammation, and inhibiting cell death. and reduce the creation of abnormal blood vessels This effectively prevents and delays macular degeneration in the elderly.