Resveratrol is a polyphenol found in many plants. Including Mulberry (Mulberry) with many biological properties...

Resveratrol is a polyphenol found in many plants. Including Mulberry, it has several biological properties that help prevent and alleviate gout (Gout) as follows:

Biological mechanisms of resveratrol in the prevention and treatment of gout.

1. Inhibits the creation of uric acid (Uric Acid).

Resveratrol can Inhibits xanthine oxidase (XO), the main enzyme that converts purines to uric acid.

Causes the level of uric acid in the blood to decrease. which is the main factor in the development of gout.

2. Anti-inflammatory (Anti-inflammatory Effect)

Resveratrol reduces the secretion of inflammatory cytokines such as IL-1β, IL-6, TNF-α.

Inhibits the activity of NF-κB, a transcription factor that stimulates inflammation.

Helps reduce pain, swelling, and redness caused by the crystallization of uric acid in the joints.

3. Antioxidant Effect

Resveratrol increases the activity of antioxidant enzymes such as SOD (superoxide dismutase), CAT (catalase), and GSH (glutathione).

Reduce damage to cells in the joints from oxidative stress caused by high uric acid.

4. Balancing the functioning of the immune system

Resveratrol helps Reduce the stimulation of white blood cells (neutrophils) that respond to uric acid crystals

Helps reduce acute inflammation in the joints that is a prominent feature of gout.

Results from using resveratrol in gout patients

Reduce the frequency of gout attacks

Reduce uric acid levels in the blood

Reduce pain and inflammation of joints

Prevents long-term joint damage.