Mechanism of action of resveratrol from mulberry on osteoarthritis in the elderly. It can be explained as follows:

Mechanism of action of resveratrol from mulberry on osteoarthritis in the elderly. It can be explained as follows:

1. Anti-inflammatory (Anti-inflammatory effect)

Resveratrol has anti-inflammatory properties by:

Inhibits the activity of COX-2 and iNOS enzymes, which are enzymes that stimulate the inflammatory process in joints.

Reduces the production of inflammatory cytokines such as IL-1β, IL-6, and TNF-α, which play an important role in destroying cartilage in the knee joint.

2. Protect cartilage cells (Chondroprotective effect)

Resveratrol stimulates the expression of genes involved in regeneration. Collagen type II and Aggrecan, which are the main components of cartilage

Inhibits the enzyme MMPs (Matrix Metalloproteinases), which is an important factor in the degradation of cartilage.

3. Antioxidant effect

Resveratrol increases the activity of antioxidant enzymes such as SOD (Superoxide Dismutase) and Catalase.

Reduce the occurrence of ROS (Reactive Oxygen Species) that destroy cartilage cells and stimulate inflammation.

4. Inhibits cell death (Anti-apoptotic effect)

Prevents the death of cartilage cells (Chondrocytes) that are caused by oxidative stress and inflammation.

Stimulates the expression of anti-apoptotic proteins such as Bcl-2.

Summary:

Resveratrol extracted from mulberry helps slow down the deterioration of knee joints in the elderly. By reducing inflammation Inhibits cartilage destruction Anti-oxidant and protects cartilage cells from death This reduces pain, swelling and increases the ability to move the knee joint.