This is an article that tells both the history of the discovery of resveratrol from the French Paradox project and delves into the biological mechanisms of it. Resveratrol...
This is an article that tells both the history of the discovery of resveratrol from the French Paradox project and delves into the biological mechanisms of it. Resveratrol from 100% natural mulberry has beneficial effects at the molecular level on the prevention and treatment of cancer and non-communicable diseases (NCDs):
Mulberry resveratrol: From the French Paradox to molecular chronic disease prevention.
1. Starting from the French Paradox: Questions that Changed the Health Industry
In the late 1980s, a group of scientists in France and the United States A strange observation has been discovered called the French Paradox, which refers to the phenomenon that the French have a low rate of heart disease. Even if you regularly eat high-fat foods like butter, cheese, and red meat.
The summary explanation is Drinking red wine in moderation It's part of French food culture. which leads to in-depth research Until being able to separate the important substance in red wine, that is, Resveratrol, a compound in the polyphenol group found in the skins of red grapes.
Later it was found that Mulberry, which is a native plant in Asia, Especially Thai breeds It has a higher amount of resveratrol than other plants. And the important thing is that it can be extracted 100% without relying on alcohol. Therefore, it is a pure source of resveratrol that is suitable for long-term health care.
2. Biological mechanism of resveratrol extracted from mulberry at the molecular level
2.1 Antioxidant Defense
Resveratrol from mulberry stimulates the production of Antioxidant enzymes include SOD, Catalase, and Glutathione peroxidase.
Helps reduce DNA damage caused by oxidative stress, which is the starting point for mutations and cancer cells.
2.2 Anti-chronic inflammation (Anti-inflammatory)
Inhibits inflammatory signals through reducing the levels of NF-κB and COX-2, which play an important role in inflammatory processes related to NCDs such as diabetes, cardiovascular disease, hepatitis, and cancer, etc.
2.3 Stimulate longevity genes (SIRT1 Activation)
Mulberry resveratrol activates the SIRT1 protein, a gene involved in cell lifespan, DNA repair and autophagy.
As a result, the body slows down cell degeneration. and prevent the accumulation of toxins within cells
2.4 Resists the division of cancer cells (Anti-cancer Mechanism)
Resveratrol blocks the activity of Cyclin and CDK proteins that are necessary for cancer cell division.
Stimulates apoptosis (abnormal cell death) by increasing the activity of p53, Bax and Caspase-3.
Prevents Angiogenesis or the creation of new blood vessels that feed cancer cells. Thus helping to limit the growth of cancerous tumors.
2.5 Balancing metabolism and blood sugar
Increases cell sensitivity to insulin (Insulin Sensitivity) and reduces insulin resistance.
As a result, blood sugar levels decrease. Prevents type 2 diabetes and obesity.
3. Outstanding benefits of resveratrol from mulberry towards chronic diseases (NCDs)
Cancer: Inhibits cancer cell growth, stimulates Apoptosis, reduces inflammation and Prevent DNA damage
Cardiovascular disease: Reduces LDL, increases HDL, prevents atherosclerosis and platelet adhesion.
Diabetes: Increases insulin sensitivity, reduces sugar levels and fat accumulation.
Liver and kidney disease: Prevents inflammation and reduces fibrosis in the organs.
Dementia (Alzheimer's): Reduces the accumulation of beta amyloid, reduces inflammation in the brain.
Summary: From nature to cellular health
100% natural mulberry resveratrol is not only a powerful antioxidant. But there are also molecular mechanisms that support the prevention of chronic disease and systematically enhance the body's functioning. It is truly another option for in-depth health care from nature.