Study of derivatives of “Resveratrol” (Resveratrol analogues) is said to be able to inhibit breast cancer. Triple-Negative Breast Ca...

Summary of articles studying derivatives of “Resveratrol” (Resveratrol analogues) is said to be able to inhibit breast cancer. Triple-Negative Breast Cancer (TNBC) or not? TNBC is a cancer that is difficult to treat. Because it does not have estrogen (ER), progesterone (PR) and HER2 receptors, it cannot be used with conventional hormonal drugs.

Research highlights: Resveratrol and 28 derivatives were tested on several types of breast cancer cells: ER-positive and TNBC (ER-negative).

The results were found: Some derivatives were clearly more potent than regular resveratrol. Can reduce the survival of cancer cells. dose-dependent (the more you use, the more inhibition)

It affects the shape and behavior of cancer cells. In a “surprising” twist, resveratrol was originally thought to act through the estrogen receptor (ERα) because of its similar structure to estrogen, but TNBC does not contain ERα.

However, this research found:

Some derivatives still kill TNBC cells, indicating that they act through "other mechanisms" that do not rely on ERα.

Mechanism discovered: Researchers examine biological pathways in cells These substances have been found to be associated with:

1. Stimulate the death of cancer cells (Apoptosis)

Cancer cells are stimulated to enter the process of “killing themselves”.

This was confirmed with a caspase assay, which is a measure of apoptosis.

2. Disturbs DNA repair

Cancer cells have more DNA damage and are less able to repair themselves. Make it stop dividing or die.

medical meaning This research indicates:

Resveratrol-modified stilbene represents a novel approach to treating TNBC, especially in patients who do not respond to hormone therapy. and may be developed into chemotherapy or combination therapy in the future

Brief summary

Research has found that Some “resveratrol derivatives” are effective against certain types of breast cancer. Triple-Negative It is stronger than regular resveratrol and can act even in the absence of estrogen receptors (ERα) by causing cancer cell death and interfering with DNA repair. Therefore, it is an interesting approach for the development of drugs to treat TNBC in the future.