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T cells (T cells) are a type of white blood cell in the adaptive immune system. They play an important role in remembering...
T cells (T cells) are a type of white blood cell in the adaptive immune system. They play an important role in recognizing and eliminating abnormal cells such as cancer cells, especially Cytotoxic T lymphocytes (CTLs) or CD8+ T cells, which have the ability to directly kill target cells.
The mechanism of action of T cells in eliminating cancer cells.
1. Recognize antigens on cancer cells
Cancer cells express abnormal antigens on their surface along with MHC class I.
T cells use the T-cell receptor (TCR) to bind to the antigen to begin the destruction process.
2. Directly destroy cancer cells
Release perforin and granzymes to penetrate cancer cell membranes and induce apoptosis.
3. Additional immune stimulation
Secretes IFN-γ and other cytokines to enhance the function of NK cells, macrophages, and other types of T cells.
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Resveratrol extracted from mulberry fruit and T cells
Resveratrol from mulberry has the effect of boosting the immune system, especially in T cells, as follows:
Mechanism of resveratrol affecting T cells
1. Stimulate the increase in the number of T cells (Proliferation).
Resveratrol affects the expression of genes involved in cell division, such as the IL-2 and STAT5 pathways, resulting in faster proliferation of T cells.
2. Increase the efficiency of destroying cancer cells.
Increased expression of perforin, granzyme B and FasL, which are important tools of CTLs in killing cancer cells.
3. Enhance immune memory (Immunological memory)
It helps the body recognize cancer cell antigens and respond more quickly if they recur.
4. Reduce chronic inflammation that inhibits T cells.
Antioxidants and reduce inflammatory substances such as TNF-α, IL-6 create an appropriate immune environment for T cells to function.
Summary:
Resveratrol extracted from mulberry fruit Helps strengthen the immune system by stimulating T cells to increase their number and increase their power to destroy cancer cells. along with balancing the environment in the body to be conducive to controlling abnormal cells which is a natural mechanism for preventing and resisting cancer