NK cells (Natural Killer cells) are a type of white blood cell that is in the innate immune system (innate immune system)...

NK cells (Natural Killer cells) are a type of white blood cell that is in the innate immune system. They play an important role in eliminating abnormal cells such as cancer cells and cells infected with viruses. without having to undergo stimulation before like T-cells

Mechanism of action of NK cells in eliminating cancer cells

1. Detect abnormal cells – NK cells have receptors on their cell surface that can detect the level of MHC class I molecule on target cells. Cancer cells often have abnormally low levels of MHC-I, causing NK cells to recognize them as a threat.

2. Release cell killing substances – When cancer cells are found, NK cells release perforin and granzymes, which destroy cell membranes and cause cancer cells to die through apoptosis.

3. Secrete cytokines such as IFN-γ to stimulate other immune systems to help eliminate cancer cells.

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Resveratrol extracted from mulberry fruit and NK cells

Resveratrol is a natural polyphenol found in red grapes. and mulberry It has many biological activities. Including strengthening the immune system and fighting cancer. Especially with NK cells:

Mechanism of resveratrol that enhances NK cell function

1. Increase the number of NK cells

Resveratrol can stimulate NK cell division through stimulating cytokines such as IL-2 and IL-15, which are important factors in NK cell growth.

2. Increase the ability to kill cancer cells

Stimulates the expression of perforin and granzymes, making NK cells have more power to destroy cancer cells.

Increases production of IFN-γ, which plays a role in stimulating co-immunity.

3. Antioxidants reduce inflammation.

Reduce oxidative stress and inflammation that are one of the causes of suppressing immune function.

4. Prevent the avoidance of cancer.

Resveratrol blocks mechanisms that cancer cells use to escape NK cells, such as adding artificial MHC-I to the cell surface.

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Summary:

Resveratrol from mulberry is a natural substance that has the potential to Enhance the work of NK cells in terms of both number and efficiency. Helps the body to fight cancer cells better. Therefore, it is a guideline for promoting health and preventing cancer through natural methods.