"Cancer must not be You must be smart and know how to prevent. Prevention is better than cure.
"Cancer must not be You must be smart and know how to prevent. Prevention is better than cure.
Explain the mechanism of cancer prevention. From resveratrol extracted from mulberries.
Resveratrol is a natural polyphenol found in plants, especially in mulberries, which has the potential to Prevent cancer Through several biological mechanisms as follows:
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1. Antioxidant Activity
Resveratrol can Eliminate or inhibit free radicals that cause damage to cellular DNA.
Reducing damage to DNA reduces the risk of mutation. which is the beginning of cancer
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2. Inhibits the activation and expression of cancer-related genes.
Resveratrol can Inhibits the activity of cancer-causing genes such as Cyclin D1, COX-2, Bcl-2, NF-κB.
Stimulates the expression of genes that help prevent cancer, such as p53, Bax.
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3. Inhibits the division and growth of cancer cells.
Resveratrol is effective Inhibit the cell cycle (Cell cycle arrest), especially in the G1/S and G2/M phases, causing cancer cells to be unable to continue dividing.
As a result, the proliferation of cancer cells is slowed down or stopped.
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4. Stimulate the process of programmed cell death (Apoptosis).
Resveratrol stimulates the Intrinsic and Extrinsic pathways of Apoptosis.
As a result, cancer cells enter the process of self-destruction without causing inflammation in surrounding tissues.
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5. Anti-inflammatory (Anti-inflammatory Effect)
Reduce the secretion of substances that cause inflammation such as TNF-α, IL-6, IL-1β.
Reducing inflammation at the cellular and tissue levels Helps reduce the chance of mutation and cancer.
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6. Resists the creation of new blood vessels in cancer tumors. (Anti-angiogenesis)
Resveratrol blocks the secretion of VEGF (Vascular Endothelial Growth Factor), which is needed to create new blood vessels to feed cancer tumors.
As a result, the tumor lacks nutrients and oxygen. It causes slow growth or deterioration.
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7. Inhibits the spread of cancer cells (Anti-metastasis)
Reduces the activity of MMPs (Matrix Metalloproteinases) enzymes that play a role in destroying surrounding tissues. for cancer cells to spread
As a result, cancer cells cannot move or invade other tissues.