Avoiding the carcinogen aflatoxin Contaminating food may be difficult because aflatoxin contaminates the staple food of Thai people. A...
Avoiding the carcinogen aflatoxin Contaminating food may be difficult because aflatoxin contaminates the staple food of Thai people. Detoxifying Aflatoxins with Resveratrol It would be a good choice. That will reduce the risk of getting cancer.
Resveratrol, a natural polyphenol It has the ability to detoxify from aflatoxin B1 (AFB1) by reducing oxidative stress and apoptosis. and regulates m6A mRNA methylation, which plays a role in gene expression.
Here is a more detailed explanation:
Aflatoxin B1 (AFB1) poisoning:
AFB1 is a highly hepatotoxic mycotoxin found in peanuts, chili powder, dried foods and spices. It damages the liver and leads to cancer.
Protective effects of resveratrol:
Reducing oxidative stress: Resveratrol can reduce oxidative stress caused by AFB1 by scavenging free radicals and promoting the activity of antioxidant enzymes.
Inhibition of apoptosis: Studies have shown that resveratrol can inhibit apoptosis. (programmed cell death) caused by AFB1
Modifying m6A: Resveratrol alleviates AFB1-induced liver damage by reducing the accumulation of free radicals (ROS), which affects N6-methyladenosine (m6A) mRNA methylation, a process that regulates gene expression.
Mechanism of action:
Resveratrol prevents AFB1 toxicity by directly inhibiting free radicals. Stimulates the activity of antioxidant enzymes (such as glutathione peroxidase superoxide dismutase and catalase) and reduce lipid peroxidation.
It can also maintain the integrity of cell membranes. which is important for cell function and survival
Research results:
Studies in liver cells (BFH12) have shown that resveratrol can reduce lipid peroxidation and mortality induced by AFB1.
Resveratrol was found to reduce the frequency of micronuclei (MN) and chromosomal abnormalities (CA) caused by aflatoxin B2.
Resveratrol has been found to improve GSH (glutathione) levels in the liver and kidneys and reduce MDA (malonedialdehyde) levels, indicating an improvement in antioxidant/oxidant balance.