การเปิดเผยประสิทธิภาพการบำบัดของเรสเวอราทรอลในโรคอัลไซเมอร์: การทบทวนหลักฐานเชิงระบบอย่างครอบคลุม

Uncovering the therapeutic efficacy of resveratrol in Alzheimer's disease: a comprehensive systematic review of the evidence.

Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been widely studied for its potential in treating Alzheimer's disease (AD). RV has shown potential to inhibit the formation of beta-amyloid (Aβ) and nerve fiber ganglia (NFT) plaques, protect against neuronal damage and oxidative stress, reduce inflammation, and promote neuroprotection. and improve the function of the blood-brain barrier (BBB). However, Conflicting results have been reported. This requires an overall systematic review to reach unbiased conclusions regarding the treatment effectiveness of RV in AD.

Data sources and extraction

Of the 34 systematic and meta-reviews examining the relationship between RV and AD collected, six were included in this study based on specific selection criteria. To identify relevant studies A comprehensive search of peer-reviewed journals in English was performed without any restrictions. Regarding publication dates up to October 15, 2023, searches were conducted across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web of Science, and Google Scholar, using appropriate terminology relevant to the specific research area. AMSTAR-2 and ROBIS tools were also used to assess the quality and risk of bias of the included systematic reviews, respectively. Two researchers independently extracted and analyzed data. By resolving any discrepancies through consensus. What is worth noting is that This study was based on the PRIOR checklist.

data analysis

This comprehensive review presents solid evidence supporting the positive effects of RV in AD, regardless of the specific mechanisms involved. It states that six systematic and meta-reviews have unanimously concluded that RV consumption can be effective in treating AD.

Conclusion

RV has shown promising potential to benefit AD patients through various mechanisms. RV has been shown to improve brain function, reduce Aβ deposition, protect the nervous system, protect the BBB, and support mitochondrial function. Facilitates synapse modification, stabilizes tau protein, reduces oxidative stress. and reduces inflammation of the nervous system that is often associated with Alzheimer's disease.