Resveratrol shows efficacy in inhibiting cancer cell proliferation and anti-angiogenesis compared to oxyre...

Resveratrol shows efficacy in inhibiting cancer cell proliferation and anti-angiogenesis compared to oxyresveratrol in cancer cells. Squamous cells in the head and neck

Research conducted at: Interdisciplinary Pharmacology Project Graduate School Chulalongkorn University Bangkok, Thailand

Abstract: Resveratrol and its derivatives have a wide range of pharmacological effects. Several studies have shown the anti-cancer effects of resveratrol. However, little is known about the anti-cancer effects of oxyresveratrol. In this study We compared the anti-proliferative and anti-angiogenic effects of oxyresveratrol and resveratrol. Three head and neck squamous cell carcinoma cell lines (HSC-3, HN-8, and HN-30) were treated with different concentrations of resveratrol or oxyresveratrol. MTT assay showed that resveratrol and oxyresveratrol significantly inhibited cell survival in a dose-dependent manner, although ELISA and Real-time PCR showed that oxyresveratrol inhibited vascular growth factor (VEGF) expression at the mRNA and protein levels. But the reduction was lower than that of resveratrol. Overall, these results indicate that oxyresveratrol has anti-cancer properties by inhibiting cancer cell proliferation and VEGF expression. However, the efficacy of oxyresveratrol was lower compared to resveratrol.