“Resveratrol supplement prevents the development of intracranial atherosclerosis” discusses the role of resveratrol (Resv...

Summary of the article “Resveratrol supplement prevents the development of intracranial atherosclerosis” discusses the role of Resveratrol, a polyphenol from red grapes. and mulberry To prevent ischemic stroke from atherosclerosis in the brain. (Intracranial Atherosclerosis; ICAS)

Summary of important points

1. What is ICAS?

ICAS is a condition in which the arteries within the brain develop a buildup of fat and inflammation. Until the arteries become hard It is an important cause of cerebrovascular disease (Stroke).

2. Effects of Resveratrol found in research

Research has found that resveratrol can help “slow down or prevent” the occurrence of atherosclerosis in the brain through several mechanisms, including:

☆ Reduce inflammation of blood vessels.

☆ Resveratrol inhibits the activity of NF-κB, which is a stimulant of inflammation in blood vessel walls. Reducing the accumulation of inflammatory cells and fat stains.

☆ Reduce free radicals (Oxidative Stress)

Helps reduce Reactive Oxygen Species (ROS) that destroy blood vessel walls. and reduces the activation of NOX enzyme which is involved in the occurrence of ICAS.

☆ Add Nitric Oxide (NO)

Helps blood vessels expand better. Good blood circulation Reduce platelet adhesion and reduce the risk of narrowing

☆ Prevent brain cell death.

Resveratrol stimulates the Akt/GSK-3β pathway, which protects brain cells from ischemia.

3. Important experimental results

In the experiment it was found that:

The group receiving Resveratrol had less atherosclerosis in the brain.

Improved cerebral blood flow

Reduce the risk of Stroke

And there is human data that chronically taking resveratrol improves brain blood flow and memory function in people with ischemic stroke.

4. Conclusion of the article

Resveratrol has the potential to help prevent atherosclerosis in the brain. Because it has the effect:

- anti-inflammatory

- Antioxidants

- Protect brain cells

- Helps the functioning of blood vessels