Efficacy in brightening human skin tone with resveratrol and its analogues: from in vitro studies to...

Efficacy in brightening human skin with resveratrol and its analogues: from in vitro studies to cosmetic applications.

Abstract:

Antioxidants are considered useful in controlling oxidative stress associated with skin aging and pigmentation disorders. Resveratrol is a polyphenolic compound found in some plants. It has the effect of inhibiting catalytic activity. gene expression and post-translational modifications of tyrosinase. which is an important enzyme in the melanin synthesis process It is the mechanistic basis for the anti-melanogenic effects seen in melanin-producing cells. 3D skin model and animal models Resveratrol is a powerful antioxidant and regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) and sirtuin 1, and can also regulate multiple signaling pathways involved in inflammation and aging. Recent clinical studies support the efficacy of resveratrol and its analogues, such as resveratril triacetate (RTA) and resveratril triglycolate (RTG), in skin whitening and anti-aging. The results of this study suggest that resveratrol and its analogues have skin-whitening and anti-aging benefits in cosmetics.