Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy

The inhibitory potential of resveratrol in cancer metastasis: from biology to therapy.

Summary of the article: (Published 14 May 2023)

Most cancer-related deaths are caused by cancerous tumors that have spread. This makes stopping cancer metastasis a major challenge in cancer treatment. Resveratrol, a compound first reported in 1997, has anti-cancer properties. It has shown potential to inhibit cancer metastasis in pre-clinical studies. Despite these positive results But clinical trials continue to make little progress. This emphasizes the need to understand the cellular processes and signaling pathways involved in the anticancer activity of resveratrol against metastatic tumors. This review article summarizes research over the past 5 years on resveratrol's potential to prevent or treat cancer and its signaling pathways for inhibiting cancer metastasis. and evaluate the bioavailability and toxicity of resveratrol. We also discuss the challenges in using resveratrol as an anticancer drug and the current animal models used in preclinical studies. Overall, this article provides valuable insights into the development of resveratrol as an antimetastatic drug for cancer therapy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10216034/