Answer the question "Kidney disease" Actually, what is the main cause?

Answer the question "Kidney disease" Actually, what is the main cause?

Abstract

The kidneys are important organs that require extraordinarily high energy requirements to maintain metabolism. Blood flow, electrolyte and water homeostasis, nutrient absorption and hormone secretion by the body. The kidneys are second only to the heart in the number of mitochondria and oxygen utilization. Therefore, the health and status of the mitochondrial energy supply is critical to optimal kidney health and function. Mitochondria are highly diverse and dynamic organelles and function under complex regulation of bioenergetic modulation. Including changes and cleaning inside the cells. Kidney disease, whether acute kidney injury (AKI) or chronic kidney disease (CKD), is a major clinical issue in global public health with high mortality and socioeconomic burden due to the lack of effective treatment strategies. Mitochondrial treatment targets have become an important focus for modern research, with the treatment of mitochondria being able to help prevent kidney disease and slow the progression of kidney disease. A better understanding of the cellular and molecular events that control mitochondrial function in health and disease will lead to the development of better treatments.