ถ้าเพื่อนๆรู้จักไมโตคอนเดรียดีพอ เพื่อนๆจะไม่เป็นโรคอัลไซเมอร์ - พาร์กินสัน

If friends know about mitochondria well enough Friends, you won't get Alzheimer's or Parkinson's disease.

Parkinson's disease It is a type of dementia that can be called elder disease, younger sister disease, and Alzheimer's disease, although the symptoms are not the same. In Parkinson's disease, It is a matter of stiffness and stiffness of movement. There can be a lot of shaking or little shaking. Starting from one hemisphere first. And later it spread to the whole body, making it difficult to sleep, get up, stand, and walk. Later, there was abnormal balance. The facial features appear to be indifferent, without emotion, and the eyes rarely blink. Children and grandchildren are afraid that his face will be fierce.

For Alzheimer's disease Start with the current memory. It kept shrinking. I couldn't remember what I said or did. I forgot appointments. Later it spread. Until there was a problem Regarding the use of language, words, rationality, decision making, even creating new matters that have never happened before. and in the later period Having problems with muscle stiffness until stuck in bed

Of the two diseases, one may appear first. and can be followed by another disease Where at the end It is a burden to those nearby. Families who need 24-hour care

But even though the symptoms are different But the origin of the disease And the factors that cause disease to develop over time are the same and related to the health of the body as a whole. Lifestyle factors, type of food, environmental pollution, etc.

Mechanism of birth which is now widely known that Mitochondria are the energy plants of the cell, which control the cell's survival or death.

and is considered a front line fortress that recognizes and acknowledges dangers that arise from the outside, whether it be toxins or germs or abnormalities that arise from within from the debris that occurs inside the cell and abnormal genetic parts

Maintaining this balance There will be changes in shape all the time. It's like there's a change. Is it a big one or is it broken down into smaller ones? The big process (Fusion) is the merging of many mitochondria together, like diluting good things with bad things. The process of making it small, or fission, is the selection of bad things in order to release them and destroy them. and let the good things remain so that the cells do not die Live for a long time and in times of crisis Whether facing danger from within or without Including severe food shortages It will be a hibernation mode, using energy economically and recycling waste, like a hibernating bear, called autophagy.

in brain disorders such as Parkinson's There is a defect in the separation process causing the body to be small. And a gene called DNM1L that controls the production of a protein called Dynamin related protein 1 was abnormal. This gene and protein control the mitochondria. Should I fission or not? And it is the heart that must be searched and developed to see if there is anything that can modify this DNM1L.

The groundbreaking discovery comes from researchers at the University of California, Los Angeles (UCLA) and is reported in the March 24, 2022 issue of the journal Nature. A gene in Drosophila Clueless and in humans that is a mammalian orthologue or that has the same basis but found in different species is CLUH. This gene is another Drp1 regulator.

The lack of Drp1 or clueless in Drosophila or CLUH in humans will cause the mitochondria to large and elongated (elongation) and vice versa Having more will cause the division of mitochondria. (fragmentation) and cells maintain quality

The interaction between drp1 and clueless is important. Clueless and CLUH promote drp1 entry into the mitochondria. CLUH binds to the drp1 receptor regulatory mRNAs MiD49 and Mff and induces the production of the appropriate protein.

When gathering evidence and knowledge that we currently have To have mitochondria or life energy plant that is good and complete that makes cells and tissues normal It consists of the presence of the PINK1 gene that produces the protein parkin to protect cells from all dangers that affect the mitochondria. and return to the mode Save money by autophagy, with Clu joining in to help.

While the PINK1 gene is abnormal and the Parkin protein is decreased, if the Clu protein is increased in response to the abnormality, Nothing will happen to the energy plant and cells and tissues will remain normal. But when the Clu protein is unable to increase in response, You will begin to see abnormalities in the functioning of the mitochondria. and the tissue begins to be damaged, and if the Clu protein decreases even more than normal The danger will be enormous to power plants. Until this mitochondria dies, the end of the cells that have increased in quantity and number. There will be more relationships. It is accompanied by even more Parkinson's symptoms. until unable to heal or restore To return to its original condition

The results of this study The experiment was not only done in a test tube. But there is still genetic modification in Drosophila that is different from the original. and there is a downregulation of beneficial genes and proteins. But it can be helped by increasing Clu protein and when these beneficial proteins decrease. It will accelerate the damage to happen quickly and even more.

This discovery, although it is at the level of laboratory research, is that the protein CLUH in humans has the same properties as Clueless in Drosophila and opens up a window of light in delaying the onset of the disease and even relieving the disease once it has occurred. The clueless protein, when translated into Thai, may appear unfavorable, hopeless, without clues, dark, but rather the opposite, solving the mystery of the mechanism that controls the human energy system.

We still have hope.

From FB Dr. Teerawat

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