The research was done at the Cyokine Research Laboratory, Department of Bioimmunotherapy,

The research was done at the Cyokine Research Laboratory, Department of Bioimmunotherapy,

The Universiry of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

The role of resveratrol in cancer prevention and treatment

Abstract. Resveratrol, trans-3,5,4'-trihydroxystilbene. It was first discovered in the 1940s as a component of the roots of hellebore (Veratrum grandiflorum O. Loes) has been found in various plants, including grapes, berries and peanuts. In addition to its effects on the heart and blood vessels, resveratrol also has anti-cancer effects. Properties to inhibit the spread of a wide variety of cancer cells, including lymphoma and leukemia. skin cancer Breast cancer, prostate cancer stomach cancer Colon cancer Pancreatic cancer Thyroid cancer, ovarian cancer, and cervical cancer The cancer cell growth inhibitory effect of resveratrol is through cell cycle regulation of p21Cip1/WAF1, p53 and Bax; Downregulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and cIAPs; and suppression of activation of several transcription factors including NF-Î B, AP-1 and Egr-1; To inhibit protein kinases including IÎ B ·kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to regulate the degradation of genes such as COX-25-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA.