Different effects of resveratrol (Resveratrol) to induce apoptosis of cancer cells. Depends on the race...

Different effects of resveratrol (Resveratrol) to induce apoptosis of cancer cells. It depends on the type of human cancer cell.

Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells

Research was conducted at the Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Abstract: The effects of resveratrol were investigated. (Resveratrol) on human cancer cells, focusing on cell death. Specially apoptotic To try to further explain the nature of the mechanism of action. There are substantial differences in the anti-proliferative effects of resveratrol between different types of human cancer cells. While inhibition of cancer cell viability by resveratrol was observed in U937 and MOLT-4 leukemia cells, resveratrol moderately inhibited cancer cell viability in MCF-7 breast, HepG2 liver, and A549 lung cancer cells, and had little effect on cell viability in Caco-2, CT116, SW480, and colon cancer cells. After treatment with resveratrol, U937 and MOLT-4 markedly increased the number of apoptotic cells, but MCF-7 and HepG2 had early apoptosis. And DNA damage caused by resveratrol has only been found in leukemia cells. Activation of sirtuin 1 and adenosine-stimulated protein kinase. Monophosphates do not play a role in resveratrol-induced cancer cell death. Resveratrol, on the other hand, It significantly reduces Akt activation by reducing H-Ras, resulting in Bax translocation to the mitochondria in leukemia cells. This study suggests that resveratrol can induce apoptosis in human leukemia cells to a higher extent than in malignant tumor cells by reducing Akt activation due to downregulation of Ras.

Full article https://www.spandidos-publications.com/10.3892/ijo.2017.3859