Resveratrol slows the growth of cancer cells by targeting the Warburg Effect and activation. Mitochondrial metabolism

Resveratrol slows the growth of cancer cells by targeting the Warburg Effect and activation. Mitochondrial metabolism

Resveratrol slows cell growth by targeting the Warburg effect and stimulating

mitochondria metabolism

Doctoral thesis of Faculty of Mathematics and Science, Brock University St. Catharines, Ontario, Canada.

Abstract: Resveratrol (RES) is a plant-derived polyphenol that has been extensively studied for its health-promoting effects related to its ability to Resveratrol in creating a positive effect on the mitochondria. Here, the interaction between the effects of resveratrol on growth and metabolism was examined in PC3 prostate cancer cells and it was shown that the growth inhibition used Resveratrol is about increasing the fusion of the mitochondrial network. Biological Creation and cellular respiration This indicates that metabolic reprogramming to oxidative phosphorylation may be required for resveratrol's antitumor effect. Indeed, when resveratrol-induced metabolic programming Resveratrol occurs to prevent cancer cell growth in the presence of galactose or treat hypoxia-induced factor-1α (HIF-1α). Resveratrol's effects on growth and metabolism are attenuated or even abolished. Moreover, in line with the ability of resveratrol to reduce HIF-1α levels observed in cancer cells, The growth inhibitory effect of resveratrol increases under hypoxic conditions. This shows the importance of the work undertaken in this research.