Resveratrol reduces oxidative injury of lung cells. from tiny dust particles (average diameter < 2.5 μm) - ...

Resveratrol reduces oxidative injury of lung cells. from tiny dust particles (mean diameter < 2.5 μm) - by attenuating autophagy

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.

Abstract: Oxidative stress and inflammation are strongly associated with fine dust particles. (average diameter < 2.5 μm; PM2.5) - Lung injury that occurs due to autophagy, which plays an important role in various physiological conditions. Balancing cells and stress adaptation. Resveratrol is a phytoalexin that exerts potent antioxidant effects against cardiovascular and pulmonary diseases. To date, the mechanism by which resveratrol protects against PM2.5 remains to be elucidated. In this study, we investigated the effect of resveratrol on oxidative injury caused by PM2.5 dust. The role of nuclear factor erythroid and autophagy in this progress was explored. Human bronchial epithelial cells were treated with PM2.5 dust and examined for cytotoxicity and oxidative stress markers. The results showed that PM2.5 dust reduced cell survival. and increased lactate dehydrogenase levels, malondialdehyde levels and reactive oxygen species (ROS) increased when exposed to PM2.5 dust. In addition, PM2.5 dust induced a significant increase in inflammatory cytokines, including interleukin (IL)-6, IL-8, IL-1β. Meanwhile, PM2.5 dust stimulated the formation of autophagy and the related changes in nuclear factor erythroid. Human bronchial epithelial cells were also treated to have an effect against PM2.5, and resveratrol had an effect in the presence or absence. 3-methylamphetamine which is an autophagic inhibitor, found that resveratrol intervention abolished PM2.5-induced oxidative injury through downregulating autophagy. Findings from this study can provide new insights into the molecular mechanism of lung interference during PM2.5 exposure.

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