Effects of resveratrol on the expression of genes involved in DNA repair in humans.

Effects of resveratrol on the expression of genes involved in DNA repair in humans.

The effect of trans-resveratrol on the

expression of the human

DNA-repair associated genes

Natural compound resveratrol (Resveratrol) which is found in some plants. It is expected to be a leading drug for extending lifespan and preventing cancer. This compound is reported to have many beneficial effects on health. Including complex stimulation and resist stress We focus on the regulation of human gene expression. and analyzed the promoter activity of several genes encoding protein factors involved in DNA repair function. In particular, the 5'-upstream region of these genes often contains duplicated GGAA-motifs that make HeLa S3 cells responsive to resveratrol. In this review We propose a molecular mechanism by which resveratrol By regulating the expression of genes involved in DNA repair, we suggest the possibility of developing new anti-aging/cancer drugs. without dangerous side effects It is based on a new concept of healing or maintaining cellular NAD+/NADH levels.

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