Resveratrol reduces cell death. (apoptosis) by inhibiting DNA damage in bronchial epithelial cells.

Resveratrol reduces cell death. (apoptosis) by inhibiting DNA damage in bronchial epithelial cells.

Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells

Abstract One of the major risk factors for the development of asthma is exposure to environmental allergens in the home. House Dust Mites (HDM) can induce DNA damage, resulting in asthma. Resveratrol (RES) has anti-apoptosis properties and affects a variety of biological processes. The aim of this study is

The protective role of resveratrol on bronchial epithelial cell apoptosis was examined. There is a high level of cell death. while resveratrol can significantly reverse this process. The induced DNA damage was greater and more severe in the house dust mite group compared with the house dust mite plus resveratrol group. This result was confirmed by immunostaining and Western blot analysis of protein expression of the DNA damage-related gene γH2AX, which is highly induced by house dust mites. Additionally, treatment with resveratrol protects bronchial epithelial cells exposed to house dust mites from DNA damage. Resveratrol reduces levels of reactive oxygen species to inhibit oxidation. that causes DNA damage in bronchial epithelial cells. In addition, when compared to the dust mite group Cell death can be attenuated by resveratrol. in the combined treatment group that increases DNA damage repair in bronchial epithelial cells

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