Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action.

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action.

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

Breast cancer (BC) is one of the most common cancers in women and accounts for the highest number of cancer-related deaths after lung cancer. The complex cancer tumor microenvironment and aggressive behavioral characteristics high spread rate and the ability to resist treatment is The most well-known features of breast cancer Therefore, it is essential to find effective therapeutic agents to overcome these harmful properties of breast cancer. Resveratrol (RES), a polyphenol and found in some plants, is used as a medicine to treat diseases such as diabetes, cardiovascular disease, inflammation, and cancer. Resveratrol's anti-cancer mechanism In terms of breast cancer These include inhibiting cancer cell proliferation and reducing cancer cell viability, invasion, and metastasis. In addition, the synergistic effect of resveratrol In combination with other chemotherapeutic agents such as docetaxel, paclitaxel, cisplatin and/or doxorubicin, it has been shown to enhance the anticancer properties of resveratrol against breast cancer cells. Although its low water solubility Resveratrol limited use They recommend using a delivery system to improve absorption. Therefore, nanotechnology delivery systems are used as a good option for resveratrol delivery. This is because of the promising potential of resveratrol as a chemopreventive and chemotherapeutic agent for breast cancer. This review aims to explore the anticancer mechanisms of resveratrol. and address the implications of using nanotechnology as a delivery system to improve the anticancer properties of resveratrol.

https://pubmed.ncbi.nlm.nih.gov/36194371/

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