Reviews about "Protective Role of Resveratrol on Aging" summarizes the main points...
Summary of review articles about "Protective Role of Resveratrol on Aging" summarizes the main idea and mechanism of action at the cellular level as follows:
1. What is Resveratrol?
It is a phytochemical in the polyphenol group that is found in abundance in the skin of red grapes, mulberries, and some plants. It has received a lot of attention in the longevity medicine community because it has outstanding properties in protecting cells and reducing the deterioration of the body with age.
2. Main cellular mechanisms for anti-aging (Anti-Aging Mechanisms)
Resveratrol slows cell aging through 4 main mechanisms:
* Longevity Gene Activation (SIRT1 Activation): Stimulates Sirtuin-1 protein, which regulates genes involved in cell repair. and simulates a condition similar to calorie restriction (Calorie Restriction), which helps extend the lifespan of cells.
* Reducing Oxidative Stress: destroys free radicals (ROS) and increases the activity of antioxidant enzymes in the body such as SOD and Catalase.
* Anti-chronic inflammation (Anti-inflammatory Action): Inhibits inflammatory mediators such as NF-κB and reduces the secretion of cytokines (Cytokines) that cause various tissues to deteriorate.
* Stimulates cell self-eating (Autophagy) and nourishes mitochondria: Helps speed up the process of eliminating cell waste or damaged proteins. and increase the efficiency of energy production of mitochondria (Cell Power Plant)
3. Benefits to various systems in the body as we age
* Vascular and cardiovascular system (Cardiovascular): Reduce platelet adhesion, reduce bad cholesterol (LDL), increase the flexibility of blood vessels. and reduce the thickness of arterial walls
* Nervous system and brain (Neuroprotection): Protects brain cells from inflammation and the accumulation of beta-amyloid protein. (Amyloid-beta), which causes Alzheimer's disease and dementia.
* Skin Aging: Protects the skin from damage by UV rays (Photoaging). Stimulates collagen production through estrogen receptors. And helps reduce wrinkles, including dark spots.
* Metabolic Health: Improves insulin sensitivity, which reduces the risk of type 2 diabetes in the elderly.