Anti-cancer effects of resveratrol (Resveratrol) through modulating the glucose metabolism of cancer tumors.

Anti-cancer effects of resveratrol (Resveratrol) through modulating the glucose metabolism of cancer tumors.

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

Preventing and treating cancer is an ongoing medical challenge. In the context of personalized medicine The polyphenol resveratrol has been well studied as an adjunct to traditional cancer treatment. that affect important processes such as inflammation, the creation of new blood vessels spread Glucose metabolism and cell death in cancer This is because resveratrol acts as a multi-targeting agent by modulating multiple signal transduction pathways. This review article focuses on the ability of resveratrol to modulate glucose metabolism in malignant tumors and its related therapeutic potential. Resveratrol reduces glucose uptake and glycolysis by affecting Glut1, PFK1, HIF-1α, ROS, PDH, and CamKKB/AMPK pathways. It also inhibits cancer cell growth, invasion, and proliferation by targeting NF-kB, Sirt1, Sirt3, LDH, PI-3K, mTOR, PKM2, R5P, G6PD, TKT, talin, and PGAM. Resveratrol also induces cancer cell death by targeting integrins, p53, LDH, and FAK. In summary, resveratrol has the potential to interfere with cancer tumor processes.

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