Academic subject "Anti-Inflammatory Properties of Resveratrol" published in the journal MDPI (International Journal of Molecul...
Summary of academic articles on "Anti-Inflammatory Properties of Resveratrol" published in the journal MDPI (International Journal of Molecular Sciences) has important points and can be summarized as follows:
1. Overview and basic features
Resveratrol (RSV) is a natural polyphenol in the stilbene family that is found in plants such as red grapes and berries.
* In addition to its outstanding properties as an antioxidant (Antioxidant), protect the heart (Cardioprotective), and protect the nervous system. (Neuroprotective) "Anti-inflammatory mechanisms" are considered the most important foundations that help reduce or inhibit the severity of various chronic diseases in humans.
2. Anti-inflammatory mechanisms at the molecular level
This article focuses on explaining the mechanisms by which resveratrol systematically blocks inflammatory processes in the body:
* Inhibits the NF-κB (Nuclear Factor Kappa B) signal pathway: Resveratrol will inhibit this signal. This is the main cog that commands genes to produce inflammatory substances in cells.
* Reduce the production of cytokines that cause inflammation. (Pro-inflammatory Cytokines): This substance significantly reduces the secretion of inflammatory mediators such as Tumor Necrosis Factor-alpha (TNF-α) and various interleukins (such as IL-6, IL-1β).
* Inhibits cyclooxygenase enzymes (COX Enzymes): Resveratrol acts to inhibit both COX-1 and COX-2 enzymes (by having a better effect on COX-2, which is the main culprit of inflammation and pain), resulting in the production of prostaglandins. (Prostaglandins: PGs) that cause pain and swelling to decrease.
* Control MicroRNAs levels: Stimulates the synthesis of anti-inflammatory microRNAs within human white blood cells (Monocytes).
3. Benefits and systemic effects on the body
From controlling inflammation and free radicals Resveratrol benefits the body in many ways:
* Metabolic system and obesity: Helps adjust the balance of microorganisms in the intestines (Gut Microbiota) and secretions from microorganisms. Which has a positive effect on the balance of energy metabolism (Metabolic Homeostasis) and reduces inflammation caused by fatty liver.
* Organ protection: Reduces the chance of fibrosis. (Anti-fibrotic) and abnormal cell division (Anti-proliferative) which reduces the risk of cancer and dementia.
Conclusion: This article points out that Resveratrol is a substance with great potential for use in the prevention and treatment of chronic inflammatory diseases. It has various molecular control mechanisms (Pleiotropic activity).